DBS for Parkinson’s Disease

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Find Your Freedom Again

If you are like many others with Parkinson’s disease (PD), your medication may be less effective than it once was. When your symptoms continue to limit your freedom to live life to the fullest, you and your doctor may consider a proven, safe and effective alternative—deep brain stimulation (DBS) therapy —and a therapy option like the St. Jude Medical Infinity™ DBS system.

Patients undergoing DBS therapy have shown a sustained improvement in quality of life for up to 10 years and beyond.1


Why now?

Your therapy for Parkinson’s may have started out with a single medication that helped control your symptoms for a while. If your medication was not effective or because less effective over time, your doctor may have prescribed new medication or a combination of therapies. Your journey to find the right therapy solution may have been difficult, and you may still not feel that you have symptom relief that you can count on, or perhaps the side-effects have been worse than your PD symptoms.

This kind of experience is not uncommon. Speak with your physician to determine if DBS therapy may be a logical next step if you have noticed any of the following:

  • Your carbidopal/levodopa, MAO-B inhibitor, COMY inhibitor or other medication “wearing off,” and your dose lasting for shorter period of times
  • Unexpected returns of your symptoms—referred to as “off times” or “motor fluctuations”—when your dose of medication should be working
  • Uncontrollable movements, or “dyskinesias,” after your medication has “kicked in”

95.5% of PD patients would recommend DBS therapy to others.2


Is DBS therapy for you?

If you seek greater relief from your PD symptoms than other treatments have given you, and if you have responded well to drug therapy with levodopa,3 DBS therapy may:

  • Give you more “on time,” when you are not as affected by: 
    • Tremor
    • Stiffness
    • Slowed movement
    • Gait changes4
  • Reduce “off time,” so you do not experience unexpected return of PD symptoms, even when your medication should be working4
  • Allow your doctor to lower your medication; this can reduce medical complications like dyskinesias and fluctuations5
  • Increase your quality of life, allowing you to do more of the things you did before PD6

Read more about how DBS therapy works, or contact us to request information and stay ahead of the latest new about DBS therapy.

Why St. Jude Medical? Results are clinically proven.

Demonstrating DBS therapy benefits, St. Jude Medical clinical studies have:

  • Proven that DBS therapy gives patients good quality “on” time (when symptoms are being controlled) for most of their waking hours4
  • Shown that 89% of caregivers and clinicians have rated overall patient symptom control improvement as good, very good or excellent5
  • Revealed a reduced need for medication during DBS therapy, providing relief from medication side effects6

While DBS therapy is proven to help manage PD symptoms, DBS is not a cure for PD. A system like the St. Jude Medical Infinity™ DBS system can provide therapy to manage some of the symptoms of PD, but does not cure the underlying condition. 

DBS therapy is not for everyone, so it is important to talk with your physician about the benefits and risks. DBS has risks associated with brain surgery, which may include serious complications such as coma, bleeding inside the brain, paralysis, seizures and infection. Some of these may be fatal. If side effects are intolerable or you are not satisfied with the therapy, the DBS system can be turned off or surgically removed. Learn more about the risks of DBS therapy and important safety information for the St. Jude Medical Infinity™ DBS system.

REFERENCES

1. Castrioto, A., Lozano, A. M., Poon, Y. Y., Lang, A. E., Fallis, M., & Moro, E. (2011). Ten-year outcome of subthalamic stimulation in Parkinson disease: A blind evaluation. Archives of Neurology, 68(12), 1550-1556. n = 18. http://dx.doi.org/10.1001/archneurol.2011.182
2. Okun, M. S., Gallo, B. V., Mandyburg, G., Jagid, J., Foote, K. D., Revilla, F. J., … Tagliati, M., & the St. Jude Medical DBS Study Group. (2012). Subthalamic deep brain stimulation with a constant-current device in Parkinson’s disease: An open-label randomised controlled trial. The Lancet Neurology, 11(2), 140-149. http://dx.doi.org/ 10.1016/S1474-4422(11)70308-8
3. Mayo Clinic. (2015). Parkinson's disease: Treatments and drugs. Retrieved from http://www.mayoclinic.org/diseases-conditions/parkinsons-disease/basics/treatment/con-20028488
4.Y u, H., & Neimat, J. (2008). The treatment of movement disorders by deep brain stimulation. Neurotherapeutics, 5, 26-36. http://dx.doi.org/10.1016/j.nurt.2007.10.072
5. St. Jude Medical. (2015). Data on file, Interim Report C-06-04.
6. St. Jude Medical. (2012). Data on file, Parkinson’s Study Final Report C-04-01. n = 136.