Embolization Portfolio

AMPLATZER™ Vascular Plug 4 (AVP 4) for low-profile embolization

Portfolio Overview

  • Advancing peripheral embolization with single device occlusion
  • Minimally invasive, implantable embolization devices uniquely designed for specific situations


The AMPLATZER™ Family of Vascular Plugs is a growing family of minimally invasive, implantable devices uniquely designed for specific embolization situations. 

Introducing the AMPLATZER™ Vascular Plug 4

The newest design in our AMPLATZER™ Family of Vascular Plugs, the AMPLATZER™ Vascular Plug 4 (AVP 4) features a low-profile design that extends its reach to distal vasculature. Its multilayered, double-lobed design provides rapid3 embolization. 

Watch our introduction to this product; then view additional chapters to learn more, including device components, size preparation and placement. See additional chapters.

Learn more about the AVP 4 and our family of vascular plug devices.

AMPLATZER™ Family of Vascular Plugs

The AMPLATZER™ Family of Vascular Plugs provides full cross-sectional vessel coverage for single-device occlusion. The plugs are designed for controlled, precise deployment and can be captured and repositioned.

Efficient and Cost-Effective

Vascular plugs are an efficient and cost-effective1,2 method of achieving peripheral embolization and have been clinically proven to improve: 

  • Speed—reduction in procedure times4 
  • Efficiency—reduction in materials used
  • Radiation exposure—reduction in radiation times4
  • Cost-effectiveness—reduction in procedural costs4
Bar graph displays improvement in times between AVP II and coils
Drawing of two arteries in the heart with arrows showing direction of blood flow

Transforming the Treatment of Cardiovascular Disease

Cardiovascular disease is the leading cause of death for both men and women worldwide, with billions of dollars spent globally on its diagnosis, management and treatment.5,6 An estimated 7.3 million people worldwide die each year from coronary artery disease alone.7 Our vision is to transform the treatment of cardiovascular disease by creating cost-effective technologies that save and improve lives. 

Learn more about our approach to cardiovascular disease.


1. Ha, C., & Calcagno, D. (2005). Amplatzer Vascular Plug to occlude the internal iliac arteries in patients undergoing aortoiliac aneurysm repair. Journal of Vascular Surgery, 42(6), 1058-1062. http://dx.doi.org/10.1016/j.jvs.2005.08.017
2. Klein, G. E., Szolar, D. H., Karaic, R., Stein, J. K., Hausegger, K. A, & Schreyer, H. H. (1996). Extracranial aneurysm and arteriovenous fistula: Embolization with the Guglielmi detachable coil. Radiology, 201(2), 489-494. http://dx.doi.org/10.1148/radiology.201.2.8888247 
3. St. Jude Medical. Data on file, Reports 301659 and 90153454.
4. Pech, M., Kraetsch, A., Wieners, G., Redlich, U., Gaffke, G., Ricke, J., & Dudeck, O. (2009). Embolization of the gastroduodenal artery before selective internal radiotherapy: A prospectively randomized trial comparing platinum-fibered microcoils with the Amplatzer Vascular Plug II. Cardiovascular and Interventional Radiology, 32(3), 455-461. http://dx.doi.org/10.1007/s00270-008-9498-y
5. Centers for Disease Control and Prevention. Heart disease facts. Retrieved from http://www.cdc.gov/heartdisease/facts.htm
6. Bloom, D. E., Cafiero, E. T., Jané-Llopis, E., Bloom, D. E., Cafiero, E. T., Jané-Llopis, E. ... Weinstein, C. (2011, September).The global economic burden of noncommunicable diseases. Presented at the meeting of the World Economic Forum. Geneva, Switzerland. http://www3.weforum.org/docs/WEF_Harvard_HE_GlobalEconomicBurdenNonCommunicableDiseases_2011.pdf
7. World Health Organization (WHO). (2011). Global Status Report on Noncommunicable Diseases 2010. Geneva, Switzerland. Retrieved from http://www.who.int/nmh/publications/ncd_report_full_en.pdf

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